HLA in ankylosing spondylitis: is HLA-B27 the only MHC gene involved in disease pathogenesis?

doi:10.1016/0049-0172(94)90026-4

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Article

HLA in ankylosing spondylitis: is HLA-B27 the only MHC gene involved in disease pathogenesis?

Seminars in arthritis and rheumatism - 1 Apr 1994

Reveille J D, Suarez Almazor M E, Russell A S, Go R C, Appleyard J, Barger B O, Acton R T, Koopman W J, McDaniel D O

Abstract excerpt

Linkage analysis of HLA haplotypes, HLA-B27 subtypes, and a 9.2-kb PvuII B7 restriction fragment length polymorphism (RFLP) (shown previously to be associated with peripheral arthritis in ankylosing spondylitis [AS]) in 115 relatives from 12 multiplex spondyloarthropathy (SNSA) and 2 B27-positive...

Topics

Alleles
Chromosome Mapping
DNA
Family Health
Female
Gene Frequency
Genes, MHC Class I
Genetic Linkage
HLA Antigens
HLA-A Antigens
HLA-B27 Antigen
Humans
Male
Pedigree
Polymorphism, Restriction Fragment Length

Source

Open in PubMed

Identifiers

PMID: 7913556
DOI: 10.1016/0049-0172(94)90026-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7913556-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Spondylitis, Ankylosing