Article
Ankylosing spondylitis and HLA-B27: restriction fragment length polymorphism and sequencing of an HLA-B27 allele from a patient with ankylosing spondylitis.
Annals of the rheumatic diseases - 1 Jul 1992
Higgins C M, Lund T, Shipley M E, Ebringer A, Sadowska-Wroblewska M, Craig R K
Abstract excerpt
Two groups of patients with ankylosing spondylitis (AS) from England and Poland were examined for restriction fragment length polymorphisms (RFLPs) associated with the disease. No preferential association was found between the 9.2 kb PvuII fragment in HLA-B27 positive patients with AS compared with HLA-B27 healthy subjects as had been previously reported. In the English group, however, a 14 kb PvuII fragment was...
Topics
- Alleles
- Autoradiography
- Base Sequence
- Blotting, Southern
- Female
- Genes, MHC Class I
- HLA-B27 Antigen
- Humans
- Male
- Molecular Sequence Data
- Polymorphism, Restriction Fragment Length