Article
The effect of HLA-DR genes on susceptibility to and severity of ankylosing spondylitis.
Arthritis and rheumatism - 1 Mar 1998
Brown M A, Kennedy L G, Darke C, Gibson K, Pile K D, Shatford J L, Taylor A, Calin A, Wordsworth B P
Abstract excerpt
OBJECTIVE: To analyze the effect of HLA-DR genes on susceptibility to and severity of ankylosing spondylitis (AS). METHODS: Three hundred sixty-three white British AS patients were studied; 149 were carefully assessed for a range of clinical manifestations, and disease severity was assessed using a structured questionnaire. Limited HLA class I typing and complete HLA-DR typing were performed using DNA-based...
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