Article
Multiple endocrine neoplasia type II and familial medullary thyroid carcinoma. Impact of genetic screening on management.
Cancer treatment and research - 1 Jan 1997
Gagel R F
Abstract excerpt
The identification of ret protooncogene mutations in MEN-II and Hirschsprung disease has not only improved the clinical management of these genetic conditions but has also provided important information regarding mechanisms of transformation and neural crest development. An indication of how neural-crest cells migrate during embryonic life and the key processes involved in their differentiation now seems within...
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