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Approach to the Patient: Hereditary Medullary Thyroid Carcinoma

19 Mar 2025

Abstract excerpt

Medullary thyroid carcinoma is a rare neuroendocrine tumor originating from calcitonin-secreting parafollicular C cells of the thyroid gland. Approximately 25% of cases in adults are hereditary medullary thyroid carcinoma (hMTC), arising from activating, germline pathogenic variants in the REarranged during Transfection (RET) proto-oncogene and causing the syndromes multiple endocrine neoplasia (MEN) types 2A and...

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PMID: 40105880
DOI: 10.1210/clinem/dgaf089

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