Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Heat shock and arsenite increase expression of the multidrug resistance (MDR1) gene in human renal carcinoma cells.

1 Jan 1990

Abstract excerpt

The multidrug transporter, initially identified as a multidrug efflux pump responsible for resistance of cultured cells to natural product cytotoxic drugs, is normally expressed on the apical membranes of excretory epithelial cells in the liver, kidney, and intestine. This localization suggests that the multidrug transporter may have a normal physiological role in transporting cytotoxic compounds or metabolites....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair Mechanisms
Share to Drug Transport and Resistance Mechanisms
Share to Hepatitis B Virus Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 1967174
DOI: 10.1016/s0021-9258(19)40219-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Heat shock and arsenite increase expression of the multidrug resistance (MDR1) gene in human renal carcinoma cells.PMID 1967174Read ↗

Heat shock-independent induction of multidrug resistance by heat shock factor 1.Semantic proximity Read ↗

Heat shock and arsenite induce expression of the nonclassical class I histocompatibility HLA-G gene in tumor cell linesSemantic proximity Read ↗

Direct Involvement of the Y-box Binding Protein YB-1 in Genotoxic Stress-induced Activation of the Human Multidrug Resistance 1 GeneSemantic proximity Read ↗

Hyperthermia-induced Nuclear Translocation of Transcription Factor YB-1 Leads to Enhanced Expression of Multidrug Resistance-related ABC TransportersSemantic proximity Read ↗

Low external pH and osmotic shock increase the expression of human MDR protein.Semantic proximity Read ↗

Metastasis-associated mts1 gene expression is down-regulated by heat shock in variant cell lines of the B16 murine melanoma.Semantic proximity Read ↗

Aromatic hydrocarbon receptor (AhR).AhR nuclear translocator- and p53-mediated induction of the murine multidrug resistance mdr1 gene by 3-methylcholanthrene and benzo(a)pyrene in hepatoma cells.Semantic proximity Read ↗

Transcriptomics Unveil Canonical and Non-Canonical Heat Shock-Induced Pathways in Human Cell LinesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.