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Article

Transgenic mouse models expressing human and macaque prion protein exhibit similar prion susceptibility on a strain-dependent manner.

Scientific reports - 30 Oct 2019

Espinosa Juan Carlos, Comoy Emmanuel E, Marin-Moreno Alba, Aguilar-Calvo Patricia, Birling Marie-Christine, Pitarch José Luis, Deslys Jean-Philippe, Torres Juan María

Abstract excerpt

Cynomolgus macaque has been used for the evaluation of the zoonotic potential of prion diseases, especially for classical-Bovine Spongiform Encephalopathy (classical-BSE) infectious agent. PrP amino acid sequence is considered to play a key role in the susceptibility to prion strains and only one amino acid change may alter this susceptibility. Macaque and human-PrP sequences have only nine amino acid...

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Identifiers

PMID: 31666632
DOI: 10.1038/s41598-019-52155-z
PMCID: PMC6821920

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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