Article
The role of Rab3A in neurotransmitter release.
Nature - 9 Jun 1994
Geppert M, Bolshakov V Y, Siegelbaum S A, Takei K, De Camilli P, Hammer R E, Südhof T C
Abstract excerpt
The small GTP-binding protein Rab3A is a Rab family member that is abundant in brain synaptic vesicles. Here we show that mice in which the rab3A gene has been mutated by homologous recombination do not express Rab3A but are viable and fertile. Electrophysiological recordings in hippocampal CA1 pyramidal cells indicate that most of their synaptic parameters are also normal, although synaptic depression after...
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