Article
[Analysis of the TSH receptor gene structure in Graves' disease by a restriction fragment length polymorphism (RFLP) study].
Nihon rinsho. Japanese journal of clinical medicine - 1 Apr 1994
Monden T, Yamada M, Mori M
Abstract excerpt
We examined the structure of the TSH receptor gene in thyroid disorders, particularly in Graves' disease by a RFLP study with a cloned human TSH receptor cDNA as a probe. Southern blot analysis indicated that the TSH receptor gene is a single copy gene in the human genome. Although RFLPs were not detected in peripheral blood cells and thyroid tissues in patient with Graves' disease, significant RFLPs were found...
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