Article
Genetically based N-acetyltransferase metabolic polymorphism and low-level environmental exposure to carcinogens.
Nature - 12 May 1994
Vineis P, Bartsch H, Caporaso N, Harrington A M, Kadlubar F F, Landi M T, Malaveille C, Shields P G, Skipper P, Talaska G
Abstract excerpt
The metabolic activation or inactivation of carcinogens varies considerably in human populations, and is partly genetically determined. Inter-individual variability in the susceptibility to carcinogens may be particularly important at low degrees of environmental exposure. Examples of probable human carcinogens that present widespread low-dose exposures are environmental tobacco smoke and diesel exhaust. We have...
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