Article
Genetically based N-acetyltransferase metabolic polymorphism and low-level environmental exposure to carcinogens.
Nature - 12 May 1994
Vineis P, Bartsch H, Caporaso N, Harrington A M, Kadlubar F F, Landi M T, Malaveille C, Shields P G, Skipper P, Talaska G
Abstract excerpt
The metabolic activation or inactivation of carcinogens varies considerably in human populations, and is partly genetically determined. Inter-individual variability in the susceptibility to carcinogens may be particularly important at low degrees of environmental exposure. Examples of probable hu...
Topics
- Acetylation
- Adult
- Arylamine N-Acetyltransferase
- Biotransformation
- Caffeine
- Carcinogens, Environmental
- Cotinine
- DNA Damage
- Genotype
- Hemoglobins
- Humans
- Male
- Middle Aged
- Nicotine
- Phenotype
- Polymorphism, Restriction Fragment Length