Article
Interindividual variation in carcinogen metabolism and bladder cancer risk.
Environmental health perspectives - 1 Nov 1992
Vineis P, Ronco G
Abstract excerpt
Epidemiological studies indicate that subjects of the genetically based slow acetylator phenotype may be at higher risk for bladder cancer than fast acetylators, particularly when they are exposed to carcinogenic arylamines: N-acetylation is a detoxification step in the metabolism of some arylami...
Topics
- Acetylation
- Acetyltransferases
- Aminobiphenyl Compounds
- Carcinogens
- Dose-Response Relationship, Drug
- Genetic Variation
- Hemoglobins
- Humans
- Phenotype
- Polymorphism, Genetic
- Risk Factors
- Smoking
- Urinary Bladder Neoplasms