Article
Genetic susceptibility and occupational cancer.
La Medicina del lavoro - 1 Jan 2000
Hayes R B
Abstract excerpt
This review describes statistical models for the biological interaction of susceptibility genes and environmental exposures, as observed in epidemiologic studies. The importance of metabolic transformation of industrial carcinogens and the potential role of genetic polymorphisms in metabolic enzyme activity are outlined. Several genetic polymorphisms have been associated with cancer risk, but the link with the...
Topics
- Carcinogens
- Genetic Predisposition to Disease
- Humans
- Models, Statistical
- Neoplasms
- Occupational Diseases
- Occupational Exposure
- Polymorphism, Genetic
- Risk Factors
