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Article

Genetic predisposition to diabetic nephropathy. Evidence for a role of the angiotensin I--converting enzyme gene.

Diabetes - 1 May 1994

Doria A, Warram J H, Krolewski A S

Abstract excerpt

In search of genetic determinants of susceptibility to diabetic nephropathy, we examined the association between DNA sequence differences at the locus of angiotensin I-converting enzyme (ACE) and renal complications in 151 insulin-dependent diabetes mellitus (IDDM) patients with a diabetes duration of 16-21 years. This nested case-control study included 77 normoalbuminuric control subjects (albumin excretion rate...

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Identifiers

PMID: 7909524
DOI: 10.2337/diab.43.5.690

Genes

ACE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Genetic predisposition to diabetic nephropathy. Evidence for a role of the angiotensin I--converting enzyme gene.PMID 7909524Read ↗

Genetic predisposition to nephropathy and associated cardiovascular disease in people with type 1 diabetes: role of the angiotensinI-converting enzyme (ACE), and beyond; a narrative review.Semantic proximity Read ↗

The DD genotype of the ACE gene polymorphism is associated with diabetic nephropathy in the type-1 diabetics.Semantic proximity Read ↗

Evaluation of risk factors for the development of nephropathy in patients with IDDM: insertion/deletion angiotensin converting enzyme gene polymorphism, hypertension and metabolic control.Semantic proximity Read ↗

Association between the angiotensin-converting enzyme-insertion/deletion polymorphism and diabetic nephropathy: a methodologic appraisal and systematic review.Semantic proximity Read ↗

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Angiotensin-converting enzyme gene and diabetes mellitus.Semantic proximity Read ↗

MTHFR C677T, A1298C and ACE I/D polymorphisms as risk factors for diabetic nephropathy among type 2 diabetic patients.Semantic proximity Read ↗

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ACE variants interact with the RAS pathway to confer risk and protection against type 2 diabetic nephropathy.Semantic proximity Read ↗

Lack of association between the insertion/deletion polymorphism of the angiotensin-converting-enzyme gene and diabetic nephropathy in IDDM patients.Semantic proximity Read ↗

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