Article
Phenotypical heterogeneity of CD4+CD8+ double-positive chronic T lymphoid leukemia.
Leukemia - 1 Apr 1998
Mizuki M, Tagawa S, Machii T, Shibano M, Tatsumi E, Tsubaki K, Tako H, Yokohama A, Satou S, Nojima J, Hirota T, Kitani T
Abstract excerpt
Chronic T lymphoid leukemias are defined as leukemias of post-thymic T cells. The CD4+CD8+ double-positive (DP) phenotype is seen in a few cases. Since DP generally occurs in thymic T cells, whether the DP T leukemia cells represent thymic or peripheral T cells has been a matter of controversy. To address this issue, we studied phenotypical features in eight cases of DP T cell leukemia. Thymic DP T cells and...
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