Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expanded CD8+ T cells of murine and human CLL are driven into a senescent KLRG1+ effector memory phenotype.

Cancer immunology, immunotherapy : CII - 1 Nov 2013

Göthert Joachim Rudolf, Eisele Lewin, Klein-Hitpass Ludger, Weber Stefanie, Zesewitz Marie-Louise, Sellmann Ludger, Röth Alexander, Pircher Hanspeter, Dührsen Ulrich, Dürig Jan

Abstract excerpt

Altered numbers and functions of T cells have previously been demonstrated in chronic lymphocytic leukemia (CLL) patients. However, dynamics and specific T-cell subset alterations have not been studied in great detail. Therefore, we studied CLL blood lymphocyte subsets of individual patients in a longitudinal manner. Dynamic expansions of blood CD4 + and CD8 + T-cell numbers were consistently associated with a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cadherins
Share to CD8-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunologic Memory

Share to Lectins, C-Type

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Mice, Inbred C3H

Share to Receptors, Immunologic

Share to T-Lymphocyte Subsets

Source

Open in PubMed Open full text

Identifiers

PMID: 24022692
DOI: 10.1007/s00262-013-1473-z
PMCID: PMC11029347

Genes

KLRG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expanded CD8+ T cells of murine and human CLL are driven into a senescent KLRG1+ effector memory phenotype.PMID 24022692Read ↗

Phenotypic alteration of CD8+ T cells in chronic lymphocytic leukemia is associated with epigenetic reprogramming.Semantic proximity Read ↗

Chronic lymphocytic leukemia presence impairs antigen-specific CD8+ T-cell responses through epigenetic reprogramming towards short-lived effectorsSemantic proximity Read ↗

Immunosuppressive Treg cells acquire the phenotype of effector-T cells in chronic lymphocytic leukemia patients.Semantic proximity Read ↗

Phenotypic differences between healthy effector CTL and leukemic LGL cells support the notion of antigen-triggered clonal transformation in T-LGL leukemia.Semantic proximity Read ↗

Flow cytometric analysis of phenotypes and naïve/memory/effector T-cell subsets of T-cell large granular lymphocytic leukemia.Semantic proximity Read ↗

Expression of KLRG1 and CD127 defines distinct CD8+ subsets that differentially impact patient outcome in follicular lymphomaSemantic proximity Read ↗

Progressive change in expression of killer-like receptorsr and GPR56 expression defines the cytokine production potential of human CD4 <sup>+</sup> T memory cellsSemantic proximity Read ↗

B-cell–specific IRF4 deletion accelerates chronic lymphocytic leukemia development by enhanced tumor immune evasionSemantic proximity Read ↗

Reduced frequency of NKT-like cells in patients with progressive chronic lymphocytic leukemia.Semantic proximity Read ↗

T Cells in Chronic Lymphocytic Leukemia: A Two-Edged Sword.Semantic proximity Read ↗

Expansion of a CD8(+)PD-1(+) replicative senescence phenotype in early stage CLL patients is associated with inverted CD4:CD8 ratios and disease progression.Semantic proximity Read ↗

Expansion of T cells expressing low CD4 or CD8 levels in B-cell chronic lymphocytic leukemia: correlation with disease status and neoplastic phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.