Sindbis virus pathogenesis: phenotypic reversion of an attenuated strain to virulence by second-site intragenic suppressor mutations.

doi:10.1099/0022-1317-74-8-1691

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Article

Sindbis virus pathogenesis: phenotypic reversion of an attenuated strain to virulence by second-site intragenic suppressor mutations.

The Journal of general virology - 1 Aug 1993

Schoepp R J, Johnston R E

Abstract excerpt

Monoclonal antibodies (MAbs) specific for the E2c neutralizing antigenic site on the Sindbis virus E2 glycoprotein define a pathogenesis domain that affects neonatal mouse virulence. Sequence analysis of E2c MAb escape mutants showed that the domain included E2 amino acids 62, 96 and 159. The pat...

Topics

Animals
Antibodies, Monoclonal
Base Sequence
Mice
Molecular Sequence Data
Phenotype
Sindbis Virus
Suppression, Genetic
Viral Envelope Proteins
Virulence

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