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Article

Adaptive mutations in Sindbis virus E2 and Ross River virus E1 that allow efficient budding of chimeric viruses.

Journal of virology - 1 Mar 2000

Kim K H, Strauss E G, Strauss J H

Abstract excerpt

Alphavirus glycoproteins E2 and E1 form a heterodimer that is required for virus assembly. We have studied adaptive mutations in E2 of Sindbis virus (SIN) and E1 of Ross River virus (RR) that allow these two glycoproteins to interact more efficiently in a chimeric virus that has SIN E2 but RR E1. These mutations include K129E, K131E, and V237F in SIN E2 and S310F and C433R in RR E1. Although RR E1 and SIN E2 will...

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Identifiers

PMID: 10684281
DOI: 10.1128/jvi.74.6.2663-2670.2000
PMCID: PMC111755

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Source receipt: pubmed, retrieved 7 Sept 2026.

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