Article
Methylation patterns in pap regulatory DNA control pyelonephritis-associated pili phase variation in E. coli.
Cell - 11 Feb 1994
Braaten B A, Nou X, Kaltenbach L S, Low D A
Abstract excerpt
We have examined the roles of pap DNA methylation patterns in the regulation of the switch between phase ON and OFF pyelonephritis-associated pili (Pap) expression states in E. coli. Two Dam methyltransferase sites, GATC1028 and GATC1130, were shown previously to be differentially methylated in phase ON versus phase OFF cells. In work presented here, these sites were mutated so that they could not be methylated,...
Topics
- Bacterial Proteins
- Base Sequence
- Binding Sites
- DNA, Bacterial
- DNA-Binding Proteins
- Escherichia coli
- Escherichia coli Proteins
- Fimbriae, Bacterial
- Genes, Bacterial
- Genetic Variation
- Leucine-Responsive Regulatory Protein