Article
Phasevarions mediate random switching of gene expression in pathogenic Neisseria.
PLoS pathogens - 1 Apr 2009
Srikhanta Yogitha N, Dowideit Stefanie J, Edwards Jennifer L, Falsetta Megan L, Wu Hsing-Ju, Harrison Odile B, Fox Kate L, Seib Kate L, Maguire Tina L, Wang Andrew H-J, Maiden Martin C, Grimmond Sean M, Apicella Michael A, Jennings Michael P
Abstract excerpt
Many host-adapted bacterial pathogens contain DNA methyltransferases (mod genes) that are subject to phase-variable expression (high-frequency reversible ON/OFF switching of gene expression). In Haemophilus influenzae, the random switching of the modA gene controls expression of a phase-variable regulon of genes (a "phasevarion"), via differential methylation of the genome in the modA ON and OFF states....
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