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Article

Leucine-responsive regulatory protein plays dual roles as both an activator and a repressor of the Escherichia coli pap fimbrial operon.

Molecular microbiology - 1 Jul 1995

van der Woude M W, Kaltenbach L S, Low D A

Abstract excerpt

The expression of the pap pilus operon of Escherichia coli is under a phase-variation control mechanism in which cells undergo a reversible transition between transcriptionally active (phase ON) and inactive (phase OFF) states. In this study, we explore the roles of leucine-responsive regulatory protein (Lrp) and the histone-like protein H-NS in the regulation of pap phase variation. Our data indicate that the...

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Source

Identifiers

PMID: 7494479
DOI: 10.1111/j.1365-2958.1995.mmi_17020303.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Leucine-responsive regulatory protein plays dual roles as both an activator and a repressor of the Escherichia coli pap fimbrial operon.PMID 7494479Read ↗

Differential binding of Lrp to two sets of pap DNA binding sites mediated by Pap I regulates Pap phase variation in Escherichia coli.Semantic proximity Read ↗

Methylation patterns in pap regulatory DNA control pyelonephritis-associated pili phase variation in E. coli.Semantic proximity Read ↗

The essential role of the promoter-proximal subunit of CAP in pap phase variation: Lrp- and helical phase-dependent activation of papBA transcription by CAP from -215.Semantic proximity Read ↗

Regulation of pap pilin phase variation by a mechanism involving differential dam methylation states.Semantic proximity Read ↗

Lrp stimulates phase variation of type 1 fimbriation in Escherichia coli K-12.Semantic proximity Read ↗

Regulatory interplay between pap operons in uropathogenic Escherichia coli.Semantic proximity Read ↗

Phase variation of F165(1) (Prs-like) fimbriae from Escherichia coli causing septicaemia in animals.Semantic proximity Read ↗

The leucine-responsive regulatory protein binds to the fim switch to control phase variation of type 1 fimbrial expression in Escherichia coli K-12.Semantic proximity Read ↗

H-NS controls pap and daa fimbrial transcription in Escherichia coli in response to multiple environmental cues.Semantic proximity Read ↗

The H-NS protein modulates the activation of the ilvIH operon of Escherichia coli K12 by Lrp, the leucine regulatory protein.Semantic proximity Read ↗

Use of a two-color genetic screen to identify a domain of the global regulator Lrp that is specifically required for pap phase variation.Semantic proximity Read ↗

Identification of an Escherichia coli genetic locus involved in thermoregulation of the pap operon.Semantic proximity Read ↗

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