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Article

Phasevarion mediated epigenetic gene regulation in Helicobacter pylori.

PloS one - 1 Jan 2011

Srikhanta Yogitha N, Gorrell Rebecca J, Steen Jason A, Gawthorne Jayde A, Kwok Terry, Grimmond Sean M, Robins-Browne Roy M, Jennings Michael P

Abstract excerpt

Many host-adapted bacterial pathogens contain DNA methyltransferases (mod genes) that are subject to phase-variable expression (high-frequency reversible ON/OFF switching of gene expression). In Haemophilus influenzae and pathogenic Neisseria, the random switching of the modA gene, associated with a phase-variable type III restriction modification (R-M) system, controls expression of a phase-variable regulon of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 22162751
DOI: 10.1371/journal.pone.0027569
PMCID: PMC3230613

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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