Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of pap pilin phase variation by a mechanism involving differential dam methylation states.

The EMBO journal - 1 Dec 1990

Blyn L B, Braaten B A, Low D A

Abstract excerpt

Transcription of the pap pilin (papA) gene in Escherichia coli is subject to control by a heritable phase variation mechanism in which alternation between transcriptionally active (phase on) and inactive (phase off) states occurs. Our results suggest that phase switching occurs without DNA rearrangement of pap DNA sequences, distinguishing this system from those described for E. coli type 1 pili and Salmonella...

Topics

Amino Acid Sequence
Bacterial Outer Membrane Proteins
Bacteriophage lambda
Base Sequence
Chromosomes, Bacterial
DNA, Bacterial
Escherichia coli
Fimbriae Proteins
Gene Expression Regulation, Bacterial
Genes, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Variation

Methylation

Molecular Sequence Data

Oligonucleotide Probes

Phenotype

Plasmids

Restriction Mapping

Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 2147413
DOI: 10.1002/j.1460-2075.1990.tb07626.x
PMCID: PMC552177

Genes

GATC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2147413-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of pap pilin phase variation by a mechanism involving differential dam methylation states.PMID 2147413Read ↗

Methylation patterns in pap regulatory DNA control pyelonephritis-associated pili phase variation in E. coli.Semantic proximity Read ↗

Differential binding of Lrp to two sets of pap DNA binding sites mediated by Pap I regulates Pap phase variation in Escherichia coli.Semantic proximity Read ↗

Phase variation of Ag43 in Escherichia coli: Dam-dependent methylation abrogates OxyR binding and OxyR-mediated repression of transcription.Semantic proximity Read ↗

Phasevarions mediate random switching of gene expression in pathogenic Neisseria.Semantic proximity Read ↗

Identification of an Escherichia coli genetic locus involved in thermoregulation of the pap operon.Semantic proximity Read ↗

Site-Specific Recombination - How Simple DNA Inversions Produce Complex Phenotypic Heterogeneity in Bacterial Populations.Semantic proximity Read ↗

Leucine-responsive regulatory protein plays dual roles as both an activator and a repressor of the Escherichia coli pap fimbrial operon.Semantic proximity Read ↗

Phase variation of F165(1) (Prs-like) fimbriae from Escherichia coli causing septicaemia in animals.Semantic proximity Read ↗

Playing Dr Jekyll and Mr Hyde: combined mechanisms of phase variation in bacteria.Semantic proximity Read ↗

Phasevarion mediated epigenetic gene regulation in Helicobacter pylori.Semantic proximity Read ↗

Quorum sensing and DNA methylation play active roles in clinical <i>Burkholderia</i> phase variationSemantic proximity Read ↗

DNA methylation-dependent regulation of pef expression in Salmonella typhimurium.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.