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Article

Differential binding of Lrp to two sets of pap DNA binding sites mediated by Pap I regulates Pap phase variation in Escherichia coli.

The EMBO journal - 1 Dec 1995

Nou X, Braaten B, Kaltenbach L, Low D A

Abstract excerpt

Pyelonephritis-associated pili (Pap) expression in Escherichia coli is subject to a phase variation control mechanism that is regulated by the leucine-responsive regulatory protein (Lrp), PapI, and deoxyadenosine methylase (Dam). In previous work, we found that the differential Dam methylation of two target sites in pap regulatory DNA, GATC-I and GATC II, is essential for the transition between active and...

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Identifiers

PMID: 8846772
DOI: 10.1002/j.1460-2075.1995.tb00267.x
PMCID: PMC394697

Genes

GATC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential binding of Lrp to two sets of pap DNA binding sites mediated by Pap I regulates Pap phase variation in Escherichia coli.PMID 8846772Read ↗

Methylation patterns in pap regulatory DNA control pyelonephritis-associated pili phase variation in E. coli.Semantic proximity Read ↗

Identification of an Escherichia coli genetic locus involved in thermoregulation of the pap operon.Semantic proximity Read ↗

Regulation of pap pilin phase variation by a mechanism involving differential dam methylation states.Semantic proximity Read ↗

The essential role of the promoter-proximal subunit of CAP in pap phase variation: Lrp- and helical phase-dependent activation of papBA transcription by CAP from -215.Semantic proximity Read ↗

Use of a two-color genetic screen to identify a domain of the global regulator Lrp that is specifically required for pap phase variation.Semantic proximity Read ↗

Regulatory interplay between pap operons in uropathogenic Escherichia coli.Semantic proximity Read ↗

Escherichia coli cells lacking methylation-blocking factor (leucine-responsive regulatory protein) have precise timing of initiation of DNA replication in the cell cycle.Semantic proximity Read ↗

DNA methylation-dependent regulation of pef expression in Salmonella typhimurium.Semantic proximity Read ↗

GATC flanking sequences regulate Dam activity: evidence for how Dam specificity may influence pap expression.Semantic proximity Read ↗

Phase variation of Ag43 in Escherichia coli: Dam-dependent methylation abrogates OxyR binding and OxyR-mediated repression of transcription.Semantic proximity Read ↗

Playing Dr Jekyll and Mr Hyde: combined mechanisms of phase variation in bacteria.Semantic proximity Read ↗

Leucine-responsive regulatory protein plays dual roles as both an activator and a repressor of the Escherichia coli pap fimbrial operon.Semantic proximity Read ↗

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