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Article

Dominant unc-37 mutations suppress the movement defect of a homeodomain mutation in unc-4, a neural specificity gene in Caenorhabditis elegans.

Genetics - 1 Nov 1993

Miller D M, Niemeyer C J, Chitkara P

Abstract excerpt

The unc-4 gene of Caenorhabditis elegans encodes a homeodomain protein that defines synaptic input to ventral cord motor neurons. unc-4 mutants are unable to crawl backward because VA motor neurons are miswired with synaptic connections normally reserved for their sister cells, the VB motor neurons. These changes in connectivity are not accompanied by any visible effects upon neuronal morphology, which suggests...

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Identifiers

PMID: 7904971
DOI: 10.1093/genetics/135.3.741
PMCID: PMC1205717

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Dominant unc-37 mutations suppress the movement defect of a homeodomain mutation in unc-4, a neural specificity gene in Caenorhabditis elegans.PMID 7904971Read ↗

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Mutations in the Caenorhabditis elegans unc-4 gene alter the synaptic input to ventral cord motor neurons.Semantic proximity Read ↗

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