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Article

Expression of the unc-4 homeoprotein in Caenorhabditis elegans motor neurons specifies presynaptic input.

Development (Cambridge, England) - 1 Sept 1995

Miller D M, Niemeyer C J

Abstract excerpt

In the nematode, Caenorhabditis elegans, VA and VB motor neurons arise from a common precursor cell but adopt different morphologies and synapse with separate sets of interneurons in the ventral nerve cord. A mutation that inactivates the unc-4 homeodomain gene causes VA motor neurons to assume the VB pattern of synaptic input while retaining normal axonal polarity and output; the disconnection of VA motor...

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Identifiers

PMID: 7555714
DOI: 10.1242/dev.121.9.2877

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Expression of the unc-4 homeoprotein in Caenorhabditis elegans motor neurons specifies presynaptic input.PMID 7555714Read ↗

C. elegans unc-4 gene encodes a homeodomain protein that determines the pattern of synaptic input to specific motor neurons.Semantic proximity Read ↗

Mutations in the Caenorhabditis elegans unc-4 gene alter the synaptic input to ventral cord motor neurons.Semantic proximity Read ↗

Regulation of neurotransmitter vesicles by the homeodomain protein UNC-4 and its transcriptional corepressor UNC-37/groucho in Caenorhabditis elegans cholinergic motor neurons.Semantic proximity Read ↗

The Groucho-like transcription factor UNC-37 functions with the neural specificity gene unc-4 to govern motor neuron identity in C. elegans.Semantic proximity Read ↗

Dominant unc-37 mutations suppress the movement defect of a homeodomain mutation in unc-4, a neural specificity gene in Caenorhabditis elegans.Semantic proximity Read ↗

The conserved kinase UNC-51 acts with VAB-8 and UNC-14 to regulate axon outgrowth in C. elegans.Semantic proximity Read ↗

unc-3-dependent repression of specific motor neuron fates in Caenorhabditis elegans.Semantic proximity Read ↗

Kinesin-related gene unc-104 is required for axonal transport of synaptic vesicles in C. elegans.Semantic proximity Read ↗

Caenorhabditis elegans VEM-1, a novel membrane protein, regulates the guidance of ventral nerve cord-associated axons.Semantic proximity Read ↗

Extracellular matrix regulates UNC-6 (netrin) axon guidance by controlling the direction of intracellular UNC-40 (DCC) outgrowth activity.Semantic proximity Read ↗

The C. elegans gene vab-8 guides posteriorly directed axon outgrowth and cell migration.Semantic proximity Read ↗

A gene expression fingerprint of C. elegans embryonic motor neuronsSemantic proximity Read ↗

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