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Article

C. elegans unc-4 gene encodes a homeodomain protein that determines the pattern of synaptic input to specific motor neurons.

Nature - 27 Feb 1992

Miller D M, Shen M M, Shamu C E, Bürglin T R, Ruvkun G, Dubois M L, Ghee M, Wilson L

Abstract excerpt

The creation of neural circuits depends on the formation of synapses between specific sets of neurons. Little is known, however, of the molecular mechanisms governing synaptic choice. A mutation in the unc-4 gene alters the pattern of synaptic input to one class of motor neurons in the Caenorhabditis elegans ventral nerve cord. In unc-4(e120), the presynaptic partners of VA motor neurons are replaced with...

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PMID: 1347150
DOI: 10.1038/355841a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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C. elegans unc-4 gene encodes a homeodomain protein that determines the pattern of synaptic input to specific motor neurons.PMID 1347150Read ↗

Expression of the unc-4 homeoprotein in Caenorhabditis elegans motor neurons specifies presynaptic input.Semantic proximity Read ↗

Mutations in the Caenorhabditis elegans unc-4 gene alter the synaptic input to ventral cord motor neurons.Semantic proximity Read ↗

Dominant unc-37 mutations suppress the movement defect of a homeodomain mutation in unc-4, a neural specificity gene in Caenorhabditis elegans.Semantic proximity Read ↗

Regulation of neurotransmitter vesicles by the homeodomain protein UNC-4 and its transcriptional corepressor UNC-37/groucho in Caenorhabditis elegans cholinergic motor neurons.Semantic proximity Read ↗

The Groucho-like transcription factor UNC-37 functions with the neural specificity gene unc-4 to govern motor neuron identity in C. elegans.Semantic proximity Read ↗

Convergent genetic programs regulate similarities and differences between related motor neuron classes in Caenorhabditis elegans.Semantic proximity Read ↗

Kinesin-related gene unc-104 is required for axonal transport of synaptic vesicles in C. elegans.Semantic proximity Read ↗

ENU-3 functions in an UNC-6/netrin dependent pathway parallel to UNC-40/DCC/frazzled for outgrowth and guidance of the touch receptor neurons in C. elegans.Semantic proximity Read ↗

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A gene expression fingerprint of C. elegans embryonic motor neuronsSemantic proximity Read ↗

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