Nanoplate Digital PCR for Identification of α0-Thalassemia (SEA Deletion): Carrier Screening and Possible Application to Prenatal Diagnosis.

doi:10.3390/ijms27177846

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Article

Nanoplate Digital PCR for Identification of α0-Thalassemia (SEA Deletion): Carrier Screening and Possible Application to Prenatal Diagnosis.

International journal of molecular sciences - 2 Sept 2026

Pattrakorn Apisit, Yamsri Supawadee, Chaibunruang Attawut, Pansuwan Anupong, Tepakhan Wanicha, Singha Kritsada, Fucharoen Supan, Srivorakun Hataichanok

Abstract excerpt

The Southeast Asian deletion (--SEA), the most prevalent α0-thalassemia mutation in Southeast Asia, is a major target of regional thalassemia prevention programs. Coinheritance of α0-thalassemia with other hemoglobinopathies, particularly hemoglobin E (Hb E), complicates routine hematological screening and requires reliable molecular confirmation. This study developed and validated a duplex nanoplate digital...

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Topics

Humans
alpha-Thalassemia
Prenatal Diagnosis
Polymerase Chain Reaction
Sequence Deletion

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Female

alpha-Globins

Genetic Carrier Screening

Heterozygote

Hemoglobin E

Genotype

Pregnancy

Alleles

Source

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Identifiers

PMID: 42737742
DOI: 10.3390/ijms27177846
PMCID: PMC13565812

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