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Article

Mutations in the genes for cardiac troponin T and alpha-tropomyosin in hypertrophic cardiomyopathy.

The New England journal of medicine - 20 Apr 1995

Watkins H, McKenna W J, Thierfelder L, Suk H J, Anan R, O'Donoghue A, Spirito P, Matsumori A, Moravec C S, Seidman J G

Abstract excerpt

BACKGROUND: Familial hypertrophic cardiomyopathy can be caused by mutations in the genes for beta cardiac myosin heavy chain, alpha-tropomyosin, or cardiac troponin T. It is not known how often the disease is caused by mutations in the tropomyosin and troponin genes, and the associated clinical phenotypes have not been carefully studied. METHODS: Linkage between polymorphisms of the alpha-tropomyosin gene or the...

Topics

Adolescent
Adult
Biomarkers
Cardiomyopathy, Hypertrophic
Genetic Linkage
Humans
Lod Score
Mutation
Myosins
Phenotype
Polymorphism, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tropomyosin

Troponin

Troponin T

Source

Identifiers

PMID: 7898523
DOI: 10.1056/NEJM199504203321603

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7898523-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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