Screening single nucleotide changes to tropomyosin to identify novel cardiomyopathy mutants.

Abstract excerpt

Inherited cardiomyopathy is a broad class of heart disease that includes pathological cardiac remodeling such as hypertrophic and dilated cardiomyopathy, affecting 1/250-1/500 people worldwide. In many cases, mutations in proteins that make up the sarcomere, the basic subcellular unit of contraction, alter thin filament regulation and are the root cause of hypertrophic and dilated cardiomyopathy. Initially,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Actins
• Share to Cardiomyopathies
• Share to Models, Molecular