Article
Molecular genetics of hypertrophic cardiomyopathy.
Annual review of medicine - 1 Jan 1995
Marian A J, Roberts R
Abstract excerpt
Hypertrophic cardiomyopathy (HCM) is genetically and phenotypically a heterogeneous disease. Genes identified include the beta myosin heavy chain gene (beta MHC) on chromosome 14q1, the troponin T gene on chromosome 1q, and the alpha tropomyosin gene on chromosome 15q. In addition, a fourth locus is present on chromosome 11q11, but the gene remains to be identified. More than 35 missense mutations in the beta...
Topics
- Cardiomyopathy, Hypertrophic
- Chromosome Mapping
- Chromosomes, Human, Pair 1
- Chromosomes, Human, Pair 11
- Chromosomes, Human, Pair 14
- Chromosomes, Human, Pair 15
- DNA Mutational Analysis
- Genotype
- Humans
- Molecular Biology
- Myosins