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Article

Altered calcium homeostasis and mitochondrial dysfunction in cortical synaptic compartments of presenilin-1 mutant mice.

Journal of neurochemistry - 1 Mar 1999

Begley J G, Duan W, Chan S, Duff K, Mattson M P

Abstract excerpt

Alzheimer's disease is characterized by amyloid beta-peptide deposition, synapse loss, and neuronal death, which are correlated with cognitive impairments. Mutations in the presenilin-1 gene on chromosome 14 are causally linked to many cases of early-onset inherited Alzheimer's disease. We report that synaptosomes prepared from transgenic mice harboring presenilin-1 mutations exhibit enhanced elevations of...

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PMID: 10037474
DOI: 10.1046/j.1471-4159.1999.0721030.x

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Altered calcium homeostasis and mitochondrial dysfunction in cortical synaptic compartments of presenilin-1 mutant mice.PMID 10037474Read ↗

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