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Article

Physical and molecular genetic analysis of the multistep proteolytic maturation pathway utilized by vaccinia virus P4a protein.

The Journal of general virology - 1 Mar 1995

Whitehead S S, Bersani N A, Hruby D E

Abstract excerpt

Three potential AG*X cleavage sites have previously been identified in vaccinia virus (VV) P4a precursor, namely AG*N, AG*S and AG*T. Utilization of the COOH-proximal AG*T site in P4a leads to release of a 23 kDa product ('23K'). Here we propose that cleavage at the AG*S site alone is responsible for release of 4a, based on peptide mapping and microsequencing which demonstrated that the NH2 terminus of 4a is...

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PMID: 7897360
DOI: 10.1099/0022-1317-76-3-717

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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