Immunogenicity of the capsid precursor and a nine-amino-acid site-directed mutant of the 3C protease of foot-and-mouth disease virus coexpressed by a recombinant goatpox virus.

doi:10.1007/s00705-014-1984-8

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Article

Immunogenicity of the capsid precursor and a nine-amino-acid site-directed mutant of the 3C protease of foot-and-mouth disease virus coexpressed by a recombinant goatpox virus.

Archives of virology - 1 Jul 2014

Ma Wenge, Wei Jie, Wei Yurong, Guo Huiling, Jin Yinghong, Xue Ying, Wang Yan, Yi Zhong, Liu Liya, Huang Jiong, Wang Lijian

Abstract excerpt

The myristoylated capsid precursor mP1-2A of foot-and-mouth disease virus (FMDV), when expressed in mammalian cells and processed by the FMDV 3C protease, can self-assemble into virus-like particles (VLPs). In the present study, nine amino acids of the 3C protease were replaced by site-directed m...

Topics

3C Viral Proteases
Amino Acid Sequence
Animals
Antibodies, Neutralizing
Antibodies, Viral
Antigens, Viral
Capripoxvirus
Capsid Proteins
Cysteine Endopeptidases
Female
Foot-and-Mouth Disease Virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression Regulation, Viral

Mice

Mice, Inbred BALB C

Mutagenesis, Site-Directed

Mutation

Vaccines, Synthetic

Viral Proteins

Source

Open in PubMed

Identifiers

PMID: 24473707
DOI: 10.1007/s00705-014-1984-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-24473707-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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