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Article

Anion exchange protein in Southeast Asian ovalocytes: heterodimer formation between normal and variant subunits.

Biochemistry - 21 Mar 1995

Jennings M L, Gosselink P G

Abstract excerpt

Chemical cross-linking has been used to determine the composition of the erythrocyte band 3 protein dimer in Southeast Asian ovalocytes (SAO). Individuals with SAO are heterozygous for a mutation in which residues 400-408 of band 3 are deleted. Normal and variant protein are present in equal amounts, but the SAO protein does not transport anions or bind stilbenedisulfonates with high affinity. We find that the...

Topics

4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid
Anion Exchange Protein 1, Erythrocyte
Asia, Southeastern
Cross-Linking Reagents
Erythrocytes, Abnormal
Humans
Mutation
Sequence Deletion
Succinimides
Trypsin

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Identifiers

PMID: 7893655
DOI: 10.1021/bi00011a013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7893655-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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