Deletion in erythrocyte band 3 gene in malaria-resistant Southeast Asian ovalocytosis.

doi:10.1073/pnas.88.24.11022

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Article

Deletion in erythrocyte band 3 gene in malaria-resistant Southeast Asian ovalocytosis.

Proceedings of the National Academy of Sciences of the United States of America - 15 Dec 1991

Jarolim P, Palek J, Amato D, Hassan K, Sapak P, Nurse G T, Rubin H L, Zhai S, Sahr K E, Liu S C

Abstract excerpt

Southeast Asian ovalocytosis (SAO) is a hereditary condition that is widespread in parts of Southeast Asia. The ovalocytic erythrocytes are rigid and resistant to invasion by various malarial parasites. We have previously found that the underlying defect in SAO involves band 3 protein, the major transmembrane protein, which has abnormal structure and function. We now report two linked mutations in the erythrocyte...

Topics

Anion Exchange Protein 1, Erythrocyte
Asia, Southeastern
Base Sequence
Chromosome Deletion
Codon
DNA
Elliptocytosis, Hereditary
Exons
Female
Humans
Immunity, Innate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Introns

Malaria

Male

Molecular Sequence Data

Oligodeoxyribonucleotides

Pedigree

Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 1722314
DOI: 10.1073/pnas.88.24.11022
PMCID: PMC53065

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1722314-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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