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Article

Disruption of the Pfg27 locus by homologous recombination leads to loss of the sexual phenotype in P. falciparum.

Molecular cell - 1 Jun 1999

Lobo C A, Fujioka H, Aikawa M, Kumar N

Abstract excerpt

Transmission of malaria depends upon the differentiation and development of the sexual stages of the parasite. In Plasmodium falciparum, it is a complex, multistage process, involving the expression of a large number of sexual stage-specific proteins. Pfg27 is one such protein, abundantly expressed at the onset of gametocytogenesis. We report successful disruption of the Pfg27 locus using homologous recombination...

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PMID: 10394367
DOI: 10.1016/s1097-2765(01)80011-3

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