Disruption of the Pfg27 locus by homologous recombination leads to loss of the sexual phenotype in P. falciparum.

doi:10.1016/s1097-2765(01)80011-3

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Article

Disruption of the Pfg27 locus by homologous recombination leads to loss of the sexual phenotype in P. falciparum.

Molecular cell - 1 Jun 1999

Lobo C A, Fujioka H, Aikawa M, Kumar N

Abstract excerpt

Transmission of malaria depends upon the differentiation and development of the sexual stages of the parasite. In Plasmodium falciparum, it is a complex, multistage process, involving the expression of a large number of sexual stage-specific proteins. Pfg27 is one such protein, abundantly expressed at the onset of gametocytogenesis. We report successful disruption of the Pfg27 locus using homologous recombination...

Topics

Animals
Cell Size
Cells, Cultured
Female
Gene Deletion
Gene Expression
Genes, Essential
Genes, Protozoan
Male
Microscopy, Electron
Mutagenesis, Site-Directed
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Plasmodium falciparum

Precipitin Tests

Protozoan Proteins

RNA, Messenger

Recombination, Genetic

Transformation, Genetic

Source

Open in PubMed

Identifiers

PMID: 10394367
DOI: 10.1016/s1097-2765(01)80011-3

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