Article
[DNA typing of allelic variants of HLA-B27: HLA-B*2705 is the predominant allele of the aboriginal population of the Chukot peninsula (Eskimos and Chukchi)].
Molekuliarnaia genetika, mikrobiologiia i virusologiia - 1 Jan 2000
Krylov M Iu, Alekseeva L I, Erdes Sh, Benevolenskaia L I
Abstract excerpt
The purpose of the study was to estimate the relative frequency of the known HLA-B27 subtypes among HLA-B27 positive Chukot natives. Using oligotyping of the polymerase chain reaction amplified second and third exons of the HLA-B27 gene in 86 DNA samples from HLA-27 positive individuals were success-fully typed. All had HLA-B*2705, including nine patients with ankylosing spondylitis and Reiter's syndrome, except...
Topics
- Alleles
- Base Sequence
- DNA Primers
- Exons
- Genetics, Population
- Genotype
- HLA-B27 Antigen
- Humans
- Inuit
- Molecular Sequence Data
- Polymerase Chain Reaction