Article
Ubiquitin ligase activity of TFIIH and the transcriptional response to DNA damage.
Molecular cell - 15 Apr 2005
Takagi Yuichiro, Masuda Claudio A, Chang Wei-Hau, Komori Hirofumi, Wang Dong, Hunter Tony, Joazeiro Claudio A P, Kornberg Roger D
Abstract excerpt
Core transcription factor (TF) IIH purified from yeast possesses an E3 ubiquitin (Ub) ligase activity, which resides, at least in part, in a RING finger (RNF) domain of the Ssl1 subunit. Yeast strains mutated in the Ssl1 RNF domain are sensitive to ultraviolet (UV) light and to methyl methanesulfonate (MMS). This increased sensitivity to DNA-damaging agents does not reflect a deficiency in nucleotide excision...
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