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Article

Bioactivation of Nevirapine to a Reactive Quinone Methide: Implications for Liver Injury

13 Jul 2012

Abstract excerpt

Nevirapine (NVP) treatment is associated with a significant incidence of liver injury. We developed an anti-NVP antiserum to determine the presence and pattern of covalent binding of NVP to mouse, rat, and human hepatic tissues. Covalent binding to hepatic microsomes from male C57BL/6 mice and male Brown Norway rats was detected on Western blots; the major protein had a mass of ~55 kDa. Incubation of NVP with rat...

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PMID: 22793666
DOI: 10.1021/tx300172s

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