Article
BRAF mutations in non-small cell lung cancer: has finally Janus opened the door?
Critical reviews in oncology/hematology - 1 May 2016
Caparica Rafael, de Castro Gilberto, Gil-Bazo Ignacio, Caglevic Christian, Calogero Raffaele, Giallombardo Marco, Santos Edgardo S, Raez Luis E, Rolfo Christian
Abstract excerpt
B-Raf mutations occur in about 1-2% of non-small cell lung cancers (NSCLC). These mutations generate a permanent activation of the mitogen activated protein kinase (MAPK) pathway, which promotes tumor growth and proliferation. In the present review, we discuss B-Raf mutation epidemiology, diagnostic methods to detect B-Raf mutations, the role of B-Raf as a driver mutation and a potential therapeutic target in...
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