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Article

Transformation by v-myb correlates with trans-activation of gene expression.

Molecular and cellular biology - 1 Jun 1990

Lane T, Ibanez C, Garcia A, Graf T, Lipsick J

Abstract excerpt

The v-myb oncogene of avian myeloblastosis virus causes acute myelomonocytic leukemia in chickens and transforms avian myeloid cells in vitro. Its protein product p48v-myb is a nuclear, sequence-specific, DNA-binding protein which activates gene expression in transient DNA transfection studies. To investigate the relationship between transformation and trans-activation by v-myb, we constructed 15 in-frame linker...

Topics

Amino Acid Sequence
Animals
Avian Leukosis Virus
Avian Myeloblastosis Virus
Base Sequence
Cell Line
Cell Transformation, Neoplastic
DNA Transposable Elements
Gene Expression Regulation, Neoplastic
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Oncogene Proteins v-myb

Oncogenes

Plasmids

Quail

Restriction Mapping

Retroviridae Proteins, Oncogenic

Transcriptional Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 2160580
DOI: 10.1128/mcb.10.6.2591-2598.1990
PMCID: PMC360617

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2160580-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Transformation by v-myb correlates with trans-activation of gene expression.PMID 2160580Read ↗

Myb-induced transformation.Semantic proximity Read ↗

Mechanisms for the transformation of myeloid and erythroid cells by the nuclear oncogene V-myb.Semantic proximity Read ↗

Myb-induced chromatin remodeling at a dual enhancer/promoter element involves non-coding rna transcription and is disrupted by oncogenic mutations of v-myb.Semantic proximity Read ↗

Oncogenic mutations cause dramatic, qualitative changes in the transcriptional activity of c-Myb.Semantic proximity Read ↗

Mutations in the DNA-binding and transcriptional activation domains of v-Myb cooperate in transformation.Semantic proximity Read ↗

Definition of functional domains in P135gag-myb-ets and p48v-myb proteins required to maintain the response of neuroretina cells to basic fibroblast growth factor.Semantic proximity Read ↗

Analysis of the v-myb structural components important for transactivation of gene expression.Semantic proximity Read ↗

Differential transcriptional activation by v-myb and c-myb in animal cells and Saccharomyces cerevisiae.Semantic proximity Read ↗

v-myb and v-ets transform chicken erythroid cells and cooperate both in trans and in cis to induce distinct differentiation phenotypes.Semantic proximity Read ↗

A temperature-sensitive phenotype of avian myeloblastosis virus: determinants that influence the production of viral mRNAs.Semantic proximity Read ↗

Transcriptional activation potential of normal and tumor-associated myb isoforms does not correlate with their ability to block GCSF-induced terminal differentiation of murine myeloid precursor cells.Semantic proximity Read ↗

Extension of the DNA binding consensus of the chicken c-Myb and v-Myb proteins.Semantic proximity Read ↗

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