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Article

Transformation by v-myb correlates with trans-activation of gene expression.

Molecular and cellular biology - 1 Jun 1990

Lane T, Ibanez C, Garcia A, Graf T, Lipsick J

Abstract excerpt

The v-myb oncogene of avian myeloblastosis virus causes acute myelomonocytic leukemia in chickens and transforms avian myeloid cells in vitro. Its protein product p48v-myb is a nuclear, sequence-specific, DNA-binding protein which activates gene expression in transient DNA transfection studies. To investigate the relationship between transformation and trans-activation by v-myb, we constructed 15 in-frame linker...

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Identifiers

PMID: 2160580
DOI: 10.1128/mcb.10.6.2591-2598.1990
PMCID: PMC360617

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Transformation by v-myb correlates with trans-activation of gene expression.PMID 2160580Read ↗

Myb-induced transformation.Semantic proximity Read ↗

Mechanisms for the transformation of myeloid and erythroid cells by the nuclear oncogene V-myb.Semantic proximity Read ↗

Myb-induced chromatin remodeling at a dual enhancer/promoter element involves non-coding rna transcription and is disrupted by oncogenic mutations of v-myb.Semantic proximity Read ↗

Oncogenic mutations cause dramatic, qualitative changes in the transcriptional activity of c-Myb.Semantic proximity Read ↗

Mutations in the DNA-binding and transcriptional activation domains of v-Myb cooperate in transformation.Semantic proximity Read ↗

Definition of functional domains in P135gag-myb-ets and p48v-myb proteins required to maintain the response of neuroretina cells to basic fibroblast growth factor.Semantic proximity Read ↗

Analysis of the v-myb structural components important for transactivation of gene expression.Semantic proximity Read ↗

Differential transcriptional activation by v-myb and c-myb in animal cells and Saccharomyces cerevisiae.Semantic proximity Read ↗

v-myb and v-ets transform chicken erythroid cells and cooperate both in trans and in cis to induce distinct differentiation phenotypes.Semantic proximity Read ↗

A temperature-sensitive phenotype of avian myeloblastosis virus: determinants that influence the production of viral mRNAs.Semantic proximity Read ↗

Transcriptional activation potential of normal and tumor-associated myb isoforms does not correlate with their ability to block GCSF-induced terminal differentiation of murine myeloid precursor cells.Semantic proximity Read ↗

Extension of the DNA binding consensus of the chicken c-Myb and v-Myb proteins.Semantic proximity Read ↗

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