No association between a thyrotropin receptor gene polymorphism and Graves' disease in the female population.

doi:10.1089/thy.1997.7.31

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Article

No association between a thyrotropin receptor gene polymorphism and Graves' disease in the female population.

Thyroid : official journal of the American Thyroid Association - 1 Feb 1997

Kotsa K D, Watson P F, Weetman A P

Abstract excerpt

A polymorphism in codon 52 of the human thyrotropin receptor results in a proline to threonine substitution in the extracellular domain of the receptor, and it has been suggested that the rarer, 52Thr, allele is associated with susceptibility to Graves' disease in the female population. To invest...

Topics

Adult
Alleles
Blotting, Northern
DNA
Female
Genotype
Graves Disease
Humans
Male
Nucleic Acid Hybridization
Polymerase Chain Reaction
Polymorphism, Genetic
Receptors, Thyrotropin

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