Recombinant receptors as probes for the study of genetic stability.

Abstract excerpt

Membrane receptors coupled to GTP binding G-proteins constitute one of the largest families of proteins involved in ligand binding, signal transmission and modulation of physiological effects. A large majority of current pharmaceuticals are actually ligands for this type of receptor, including e.g. the catecholamine, dopamine, serotonin and histamine antagonists. In recent years, an impressive number of the genes...

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