p53 mutations, O6-alkylguanine DNA alkyltransferase activity, and sensitivity to procarbazine in human brain tumors.

doi:10.1002/1097-0142(19950315)75:6<1339::aid-cncr2820750616>3.0.co;2-f

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Article

p53 mutations, O6-alkylguanine DNA alkyltransferase activity, and sensitivity to procarbazine in human brain tumors.

Cancer - 15 Mar 1995

Russell S J, Ye Y W, Waber P G, Shuford M, Schold S C, Nisen P D

Abstract excerpt

BACKGROUND: In human brain tumors, sensitivity to procarbazine as measured by sensitivity in a xenograft tumor model correlated inversely with amounts of the DNA repair enzyme O6-alkylguanine DNA alkyltransferase (AT). METHODS: To test the hypothesis that mutations of the p53 tumor suppressor gene in human tumors also can correlate with the response to chemotherapy, p53 mutations2 were identified in primary human...

Topics

Animals
Base Sequence
Brain Neoplasms
Cell Cycle
DNA Mutational Analysis
DNA Repair
Genes, p53
Humans
Methyltransferases
Mice
Mice, Nude
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Neoplasm Transplantation

O(6)-Methylguanine-DNA Methyltransferase

Polymerase Chain Reaction

Procarbazine

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 7882284
DOI: 10.1002/1097-0142(19950315)75:6<1339::aid-cncr2820750616>3.0.co;2-f

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7882284-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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