O<sup>6</sup>‐methylguanine DNA methyltransferase and p53 status predict temozolomide sensitivity in human malignant glioma cells

doi:10.1111/j.1471-4159.2005.03583.x

Article

O<sup>6</sup>‐methylguanine DNA methyltransferase and p53 status predict temozolomide sensitivity in human malignant glioma cells

9 Jan 2006

Abstract excerpt

Temozolomide (TMZ) is a methylating agent which prolongs survival when administered during and after radiotherapy in the first-line treatment of glioblastoma and which also has significant activity in recurrent disease. O6-methylguanine DNA methyltransferase (MGMT) is a DNA repair enzyme attributed a role in cancer cell resistance to O6-alkylating agent-based chemotherapy. Using a panel of 12 human glioma cell...

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