Article
An rplKDelta29-PALG-32 mutation leads to reduced expression of the regulatory genes ccaR and claR and very low transcription of the ceaS2 gene for clavulanic acid biosynthesis in Streptomyces clavuligerus.
Molecular microbiology - 1 Aug 2006
Gomez-Escribano Juan Pablo, Liras Paloma, Pisabarro Agustín, Martín Juan F
Abstract excerpt
The transcriptional and translational control of the biosynthesis of the beta-lactamase inhibitor clavulanic acid is a subject of great scientific and industrial interest. To study the role of the ribosomal protein L11 on control of clavulanic acid gene transcription, the DNA region aspC-tRNA(trp)-secE-rplK-rplA-rplJ-rplL of Streptomyces clavuligerus was cloned and characterized. An S. clavuligerus...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.