CMP-N-acetylneuraminic acid hydroxylase activity determines the wheat germ agglutinin-binding phenotype in two mutants of the lymphoma cell line MDAY-D2.

doi:10.1007/BF00731295

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Article

CMP-N-acetylneuraminic acid hydroxylase activity determines the wheat germ agglutinin-binding phenotype in two mutants of the lymphoma cell line MDAY-D2.

Glycoconjugate journal - 1 Oct 1991

Shaw L, Yousefi S, Dennis J W, Schauer R

Abstract excerpt

The dominant glycosylation mutants of MDAY-D2 mouse lymphoma cells, designated class 2 (D33W25 and D34W25) were selected for their resistance to the toxic effects of wheat germ agglutinin (WGA) and shown to express elevated levels of Neu5Gc. In accordance with this, the activity of CMP-Neu5Ac hyd...

Topics

Cell Division
Ferrous Compounds
Glucosamine
Glycosylation
Kinetics
Lymphoma
Mixed Function Oxygenases
Mutation
NAD
Phenotype
Sialic Acids
Solubility
Tumor Cells, Cultured
Wheat Germ Agglutinins

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