The catalytic role of aspartic acid-92 in a human dual-specific protein-tyrosine-phosphatase.

doi:10.1021/bi00010a031

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Article

The catalytic role of aspartic acid-92 in a human dual-specific protein-tyrosine-phosphatase.

Biochemistry - 14 Mar 1995

Denu J M, Zhou G, Guo Y, Dixon J E

Abstract excerpt

The mechanism of catalysis for the human dual-specific (vaccinia H1-related) protein-tyrosine-phosphatase was investigated. The pH dependence of the kcat value is bell-shaped when p-nitrophenyl phosphate was employed as a model substrate. The kcat/Km pH profile rises with a slope of 2 and decreas...

Topics

Amino Acid Sequence
Aspartic Acid
Base Sequence
Catalysis
Conserved Sequence
DNA
Dual Specificity Phosphatase 3
Humans
Hydrogen-Ion Concentration
Iodoacetates
Iodoacetic Acid
Kinetics
Molecular Sequence Data
Molecular Structure
Mutagenesis, Site-Directed
Mutation
Nitrophenols
Organophosphorus Compounds

Source

Open in PubMed

Identifiers

PMID: 7880835
DOI: 10.1021/bi00010a031

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7880835-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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