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Article

The histidine 115-histidine 134 dyad mediates the lactonase activity of mammalian serum paraoxonases.

The Journal of biological chemistry - 17 Mar 2006

Khersonsky Olga, Tawfik Dan S

Abstract excerpt

Serum paraoxonases (PONs) are calcium-dependent lactonases that catalyze the hydrolysis and formation of a variety of lactones, with a clear preference for lipophilic lactones. However, the lactonase mechanism of mammalian PON1, a high density lipoprotein-associated enzyme that is the most studied family member, remains unclear, and other family members have not been examined at all. We present a kinetic and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16407305
DOI: 10.1074/jbc.M512594200

Genes

PON1
PON3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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