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Cysteine-191 in aspartate aminotransferases appears to be conserved due to the lack of a neutral mutation pathway to the functional equivalent, alanine-191.

Proteins - 1 Feb 1996

Gloss L M, Spencer D E, Kirsch J F

Abstract excerpt

It was previously suggested that the conserved Cys-191 of aspartate aminotransferases (AATases) is conserved, not because it is essential, but because it is frozen in the sequence, with no neutral corridor to traverse to the similar phenotype of Ala-191 (Gloss et al., Biochemistry 31:32-39, 1992). This hypothesis has now been tested by additional mutations. All possible one-base mutations from Cys were made at...

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PMID: 8820486
DOI: 10.1002/(SICI)1097-0134(199602)24:2<195::AID-PROT6>3.0.CO;2-I

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